Audio / Video

The Physics and Engineering of Advanced Microscopes for Biological Discovery

  • 01:17:22


Over the course of my career, I’ve been involved in the development of several novel microscope technologies: near-field optics, single molecule localization, lattice light sheet, structured illumination, and adaptive optics. In each case, the process has involved determining the customer’s (i.e., biologists) needs, rummaging through a physicist’s bag of tricks to see what might help solve their problem, and putting in the blood, sweat, and tears needed to engineer a practical solution when the reality turns out to be much messier than the original physical picture. I will describe this process, and some pitfalls to avoid, with the hope of illustrating a few general principles for the pursuit of impactful applied science.



The Physics and Engineering of Advanced Microscopes for Biological Discovery


University of California, Berkeley. Dept. of Physics


Berkeley, CA, University of California, Berkeley, Dept. of Physics, February 29, 2016

Full Collection Name

Physics Colloquia






1 streaming video file

Other Physical Details

digital, sd., col.


Physics Library


Recorded at a colloquium held on February 29, 2016, sponsored by the Dept. of Physics, University of California, Berkeley.

originally produced as an .mts file in 2016

Speakers: Betzig, Eric.

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Physics Colloquia


colloquia/2-29-16Betzig.mp4 01:17:22

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